Parvalbumin and GABA Microcircuits in the Mouse Superior Colliculus. 2018

Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
Fuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences - Department of Neurobiology, Semel Institute for Neuroscience and Human Behavior - Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

The mammalian superior colliculus (SC) is a sensorimotor midbrain structure responsible for orienting behaviors. Although many SC features are known, details of its intrinsic microcircuits are lacking. We used transgenic mice expressing reporter genes in parvalbumin-positive (PV+) and gamma aminobutyric acid-positive (GABA+) neurons to test the hypothesis that PV+ neurons co-localize GABA and form inhibitory circuits within the SC. We found more PV+ neurons in the superficial compared to the intermediate SC, although a larger percentage of PV+ neurons co-expressed GABA in the latter. Unlike PV+ neurons, PV+/GABA+ neurons showed predominantly rapidly inactivating spiking patterns. Optogenetic activation of PV+ neurons revealed direct and feedforward GABAergic inhibitory synaptic responses, as well as excitatory glutamatergic synapses. We propose that PV+ neurons in the SC may be specialized for a variety of circuit functions within the SC rather than forming a homogeneous, GABAergic neuronal subtype as they appear to in other regions of the brain.

UI MeSH Term Description Entries
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D010320 Parvalbumins Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process. Parvalbumin,Parvalbumin B
D005680 gamma-Aminobutyric Acid The most common inhibitory neurotransmitter in the central nervous system. 4-Aminobutyric Acid,GABA,4-Aminobutanoic Acid,Aminalon,Aminalone,Gammalon,Lithium GABA,gamma-Aminobutyric Acid, Calcium Salt (2:1),gamma-Aminobutyric Acid, Hydrochloride,gamma-Aminobutyric Acid, Monolithium Salt,gamma-Aminobutyric Acid, Monosodium Salt,gamma-Aminobutyric Acid, Zinc Salt (2:1),4 Aminobutanoic Acid,4 Aminobutyric Acid,Acid, Hydrochloride gamma-Aminobutyric,GABA, Lithium,Hydrochloride gamma-Aminobutyric Acid,gamma Aminobutyric Acid,gamma Aminobutyric Acid, Hydrochloride,gamma Aminobutyric Acid, Monolithium Salt,gamma Aminobutyric Acid, Monosodium Salt
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013477 Superior Colliculi The anterior pair of the quadrigeminal bodies which coordinate the general behavioral orienting responses to visual stimuli, such as whole-body turning, and reaching. Colliculus, Superior,Optic Lobe, Human,Optic Lobe, Mammalian,Optic Tectum,Anterior Colliculus,Superior Colliculus,Tectum, Optic,Colliculi, Superior,Colliculus, Anterior,Human Optic Lobe,Human Optic Lobes,Mammalian Optic Lobe,Mammalian Optic Lobes,Optic Lobes, Human,Optic Lobes, Mammalian,Optic Tectums,Tectums, Optic
D013569 Synapses Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions. Synapse
D059330 GABAergic Neurons Neurons whose primary neurotransmitter is GAMMA-AMINOBUTYRIC ACID. GABA Cells,GABA Neurons,Cell, GABA,Cells, GABA,GABA Cell,GABA Neuron,GABAergic Neuron,Neuron, GABA,Neuron, GABAergic,Neurons, GABA,Neurons, GABAergic
D062308 Optogenetics The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system. Optogenetic Techniques,Optogenetic,Optogenetic Technique,Technique, Optogenetic,Techniques, Optogenetic

Related Publications

Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
December 1990, Neuroscience letters,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
November 2014, Zoological science,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
January 2014, Frontiers in neural circuits,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
June 2001, Journal of neuroscience research,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
January 2008, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
September 1974, Nihon seirigaku zasshi. Journal of the Physiological Society of Japan,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
July 2000, The Anatomical record,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
May 1998, The Journal of comparative neurology,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
June 2014, Acta histochemica et cytochemica,
Claudio A Villalobos, and Qiong Wu, and Psyche H Lee, and Paul J May, and Michele A Basso
March 2015, Nature,
Copied contents to your clipboard!