Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response. 2018

Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain(1).

This prospective study evaluates whether CMV-seropositive (R+) transplant patients with pretransplant CD8+IFNG+ T-cell response to cytomegalovirus (CMV) (CD8+IFNG+ response) can spontaneously clear the CMV viral load without requiring treatment. A total of 104 transplant patients (kidney/liver) with pretransplant CD8+IFNG+ response were evaluable. This response was determined using QuantiFERON-CMV assay. The incidence of CMV replication and disease was 45.2% (47/104) and 6.7% (7/104), respectively. Of the total patients, 77.9% (81/104) did not require antiviral treatment, either because they did not have CMV replication (n = 57) or because they had asymptomatic CMV replication that could be spontaneously cleared (n = 24). Both situations are likely related to the presence of CD8+IFNG+ response to CMV, which has a key role in controlling CMV infection. However, 22.1% of the patients (23/104) received antiviral treatment, although only 7 of them did so because they had symptomatic CMV replication. These patients developed symptoms in spite of having pretransplant CD8+IFNG+ response, thus suggesting that other immunological parameters might be involved, such as a dysfunctional CD4+ response or that they might have become QFNon-reactive due to the immunosuppression. In conclusion, around 80% of R+ patients with pretransplant CD8+IFNG+ response to CMV did not require antiviral treatment, although this percentage might be underestimated. Nevertheless, other strategies such as performing an additional CD8+IFNG+ response determination at posttransplant time might provide more reliable information regarding the patients who will be able to spontaneously clear the viremia.

UI MeSH Term Description Entries
D007165 Immunosuppression Therapy Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. Antirejection Therapy,Immunosuppression,Immunosuppressive Therapy,Anti-Rejection Therapy,Therapy, Anti-Rejection,Therapy, Antirejection,Anti Rejection Therapy,Anti-Rejection Therapies,Antirejection Therapies,Immunosuppression Therapies,Immunosuppressions,Immunosuppressive Therapies,Therapies, Immunosuppression,Therapies, Immunosuppressive,Therapy, Immunosuppression,Therapy, Immunosuppressive
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D003586 Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults. CMV Inclusion,CMV Inclusions,Congenital CMV Infection,Congenital Cytomegalovirus Infection,Cytomegalic Inclusion Disease,Cytomegalovirus Colitis,Cytomegalovirus Inclusion,Cytomegalovirus Inclusion Disease,Cytomegalovirus Inclusions,Inclusion Disease,Perinatal CMV Infection,Perinatal Cytomegalovirus Infection,Renal Tubular Cytomegalovirus Inclusion,Renal Tubular Cytomegalovirus Inclusions,Salivary Gland Virus Disease,Severe Cytomegalovirus Infection,Severe Cytomegalovirus Infections,Infections, Cytomegalovirus,CMV Infection, Congenital,CMV Infection, Perinatal,Colitis, Cytomegalovirus,Congenital CMV Infections,Congenital Cytomegalovirus Infections,Cytomegalic Inclusion Diseases,Cytomegalovirus Colitides,Cytomegalovirus Inclusion Diseases,Cytomegalovirus Infection,Cytomegalovirus Infection, Congenital,Cytomegalovirus Infection, Perinatal,Cytomegalovirus Infection, Severe,Cytomegalovirus Infections, Severe,Disease, Cytomegalic Inclusion,Disease, Cytomegalovirus Inclusion,Diseases, Cytomegalovirus Inclusion,Inclusion Disease, Cytomegalic,Inclusion Disease, Cytomegalovirus,Inclusion Diseases,Inclusion Diseases, Cytomegalovirus,Inclusion, CMV,Inclusion, Cytomegalovirus,Infection, Congenital CMV,Infection, Congenital Cytomegalovirus,Infection, Cytomegalovirus,Infection, Perinatal CMV,Infection, Perinatal Cytomegalovirus,Infection, Severe Cytomegalovirus,Perinatal CMV Infections,Perinatal Cytomegalovirus Infections
D003587 Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS. Herpesvirus 5, Human,Human Herpesvirus 5,Salivary Gland Viruses,HHV 5,Herpesvirus 5 (beta), Human,Cytomegaloviruses,Salivary Gland Virus,Virus, Salivary Gland,Viruses, Salivary Gland
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
March 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
August 1998, Bone marrow transplantation,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
August 2015, Transplant infectious disease : an official journal of the Transplantation Society,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
February 2009, Transplant infectious disease : an official journal of the Transplantation Society,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
April 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
April 2014, Transplantation,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
August 1990, Transplantation proceedings,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
April 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
July 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Aurora Páez-Vega, and Antonio Poyato, and Alberto Rodriguez-Benot, and Lluis Guirado, and Jesús Fortún, and Oscar Len, and Edson Abdala, and María C Fariñas, and Elisa Cordero, and Carmen de Gracia, and Domingo Hernández, and Rafael González, and Julián Torre-Cisneros, and Sara Cantisán, and , and
June 2021, Open forum infectious diseases,
Copied contents to your clipboard!