OBJECTIVE Introduction: The number of elderly people in society is increasing. Alike in all European countries, ageing population in Ukraine is observed, which affects the structure and dynamics of morbidity and mortality of the population towards the increase of chronic non-communicable diseases, which is the epidemic of the 21st century civilization. In 2010 in Ukraine, the proportion of people over the age of 60 was 20.6% of the total. The prevalence of all diseases among the elderly in 2010 amounted to 283522,8, and among the general population - 186746,4. The first place among them is circulatory system diseases (CSD), a specific weight of which is 52.1% The aim: Aim of the study was to do an epidemiological analysis of acute myocardial infarction among the population in the Poltava region and Ukraine in the age group of 25-64 years, depending on gender, age on the basis of the WHO standard program "Register of acute myocardial infarction". METHODS Materials and methods: For the analysis of the morbidity and disability of the MI (myocardial infarction) the data of the statistical collections of the population of Ukraine for 2004-2015 were used. The incidence of the MI was analyzed according to the indicator "registered patients: adults (with the diagnosis established for the first time in life) in terms of 10 thousand population". RESULTS Review and conclusions: The incidence of AMI prevails among residents of urban areas, both in Ukraine and in the Poltava region, does not depend on the distance from the regional center, where the regional hospital and the higher educational institution are located, this indicator is significantly prevalent among people of retirement age, prevails in men.