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The effect of nicardipine on basal and pentagastrin-stimulated gastric acid secretion in normal volunteers was investigated. When compared with saline, an intravenous infusion of nicardipine caused a significant decrease in peak acid output (from 37.8 mmol hour-1 to 28.8 mmol hour-1; P = 0.04) and a small reduction in aspirate volume. Nicardipine had no significant action on basal acid output or volume of aspirate. Proteolytic activity in both the basal and stimulated periods was unaffected by nicardipine as were serum gastrin concentrations. Although calcium channel blocking agents are theoretically antisecretory the present study suggests they are unlikely to have clinically useful therapeutic actions.
A Prior, and
P J Whorwell
January 1986,
Scandinavian journal of gastroenterology. Supplement,
A Prior, and
P J Whorwell
January 1979,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
A Prior, and
P J Whorwell
February 1977,
Gut,
A Prior, and
P J Whorwell
January 1977,
Surgical forum,
A Prior, and
P J Whorwell
September 1980,
Life sciences,
A Prior, and
P J Whorwell
November 1974,
The Indian journal of medical research,
A Prior, and
P J Whorwell
February 1978,
Gut,
A Prior, and
P J Whorwell
September 1982,
Scandinavian journal of gastroenterology,
A Prior, and
P J Whorwell
December 1993,
Zeitschrift fur Gastroenterologie,
A Prior, and
P J Whorwell
January 1969,
Scandinavian journal of gastroenterology,
