BIOMAT Database Logo BIOMAT Database Logo

[The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy]. 2018

A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Pirogov Russian National Research Medical University, Moscow, Russia.

OBJECTIVE The state of microcirculation and platelet hemostasis in patients with ischemic stroke after systemic thrombolytic therapy. METHODS Forty-two patients after systemic thrombolytic therapy (TLT) (mean age 64.26 [60.58; 68.06]) and 47 patients without TLT (54.52 [47.48; 60.83]) were studied. The study of platelet hemostasis was conducted with the determination of platelet aggregation (AT) on adrenaline, ADP, ristomycin, spontaneous aggregation on days 1, 7 and 14. Studies of the state of microcirculation of cerebral vessels were carried out using the laser Doppler flowmetry (LDF). CONCLUSIONS Characteristics of changes in induced AT and parameters of the microcirculation system in patients after systemic TLT at 1, 7 and 14 days in comparison with the indices of patients without TLT were revealed that allowed to expand the understanding of pathological mechanisms of the microcirculatory bed, their connection with violations of central hemodynamics and to obtain additional markers of disease course and prognosis.

UI MeSH Term Description Entries
D008833 Microcirculation The circulation of the BLOOD through the MICROVASCULAR NETWORK. Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D002545 Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. Cerebral Ischemia,Ischemic Encephalopathy,Encephalopathy, Ischemic,Ischemia, Cerebral,Brain Ischemias,Cerebral Ischemias,Ischemia, Brain,Ischemias, Cerebral,Ischemic Encephalopathies
D006487 Hemostasis The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION. Hemostases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D015912 Thrombolytic Therapy Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts. Fibrinolytic Therapy,Thrombolysis, Therapeutic,Therapeutic Thrombolysis,Therapy, Fibrinolytic,Therapy, Thrombolytic,Fibrinolytic Therapies,Therapeutic Thrombolyses,Therapies, Fibrinolytic,Therapies, Thrombolytic,Thrombolyses, Therapeutic,Thrombolytic Therapies
D017078 Laser-Doppler Flowmetry A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates. Doppler-Laser Flowmetry,Flowmetry, Laser-Doppler,Laser-Doppler Velocimetry,Velocimetry, Laser-Doppler,Doppler Laser Flowmetry,Flowmetry, Doppler-Laser,Flowmetry, Laser Doppler,Laser Doppler Flowmetry,Laser Doppler Velocimetry,Velocimetry, Laser Doppler
D020521 Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) Apoplexy,Cerebral Stroke,Cerebrovascular Accident,Cerebrovascular Apoplexy,Vascular Accident, Brain,CVA (Cerebrovascular Accident),Cerebrovascular Accident, Acute,Cerebrovascular Stroke,Stroke, Acute,Acute Cerebrovascular Accident,Acute Cerebrovascular Accidents,Acute Stroke,Acute Strokes,Apoplexy, Cerebrovascular,Brain Vascular Accident,Brain Vascular Accidents,CVAs (Cerebrovascular Accident),Cerebral Strokes,Cerebrovascular Accidents,Cerebrovascular Accidents, Acute,Cerebrovascular Strokes,Stroke, Cerebral,Stroke, Cerebrovascular,Strokes,Strokes, Acute,Strokes, Cerebral,Strokes, Cerebrovascular,Vascular Accidents, Brain

Related Publications

A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
[Independence of ischemic stroke patients after alteplase systemic thrombolytic therapy].
January 2021, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Systemic thrombolytic therapy of acute ischemic stroke with rtPA.
March 2002, Expert review of neurotherapeutics,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
[State of the blood platelet link of hemostasis and microcirculation in patients with ischemic heart disease during plasmapheresis treatment].
December 1989, Kardiologiia,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Thrombolytic therapy in patients with acute ischemic stroke.
October 2000, Archives of neurology,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
PROSPECTIVE PILOT STUDY TO ASSESS MOTOR ACTIVITY AND THE STATE OF THE HEMOSTASIS SYSTEM IN THE ACUTE PERIOD OF ISCHEMIC STROKE DURING SYSTEMIC THROMBOLYTIC THERAPY.
January 2021, Wiadomosci lekarskie (Warsaw, Poland : 1960),
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Treatment of ischemic stroke complicating cardiac catheterization with systemic thrombolytic therapy.
November 2005, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
[Computer tomographic and laboratory predictors of clinical outcomes of acute ischemic stroke patients after the systemic thrombolytic therapy].
January 2010, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Intracerebral hemorrhage after thrombolytic therapy in acute ischemic stroke patients with renal dysfunction.
January 2013, European neurology,
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
Study on the Baseline Factors and Platelet Indices That Predict Outcome of Acute Ischemic Stroke Patients after Thrombolytic Therapy.
January 2022, Cerebrovascular diseases (Basel, Switzerland),
A V Anisimova, and S S Galkin, and A I Krupatkin, and V V Sidorov, and A S Gunchenko
[Thrombolytic therapy of ischemic stroke].
January 2018, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
Copied contents to your clipboard!