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Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
January 1984,
AIDS research,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
March 1986,
Human pathology,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
October 1985,
The Practitioner,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
June 1986,
Nursing,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
August 1985,
Human pathology,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
September 1986,
Annals of neurology,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
July 1986,
Quintessenz Journal,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
January 1986,
Pennsylvania medicine,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
January 1986,
International review of experimental pathology,
G M Shaw, and
M E Harper, and
B H Hahn, and
L G Epstein, and
D C Gajdusek, and
R W Price, and
B A Navia, and
C K Petito, and
C J O'Hara, and
J E Groopman
January 1987,
Gaceta medica de Mexico,
