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The therapeutic effect of Vitamin B12 or Vitamin B6 on 2,5-hexanedione induced-neuropathy in animals was examined by using our electrodiagnostic technique in order to investigate the mechanism of the development of the neuropathy. Pyridoxal phosphate and two forms of Vitamin B12 were administered to rats intoxicated by the neurotoxin for a period of 18 weeks, and the sensory and motor fiber conduction velocity and the motor distal latency of the tail nerve were periodically determined. None of the groups treated with the therapeutic drugs exhibited a definite improvement in the nerve fiber conduction velocity and motor distal latency of the rat tail nerve, as compared with those of the 2,5-hexanedione-treated controls.
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
January 1982,
Neurobehavioral toxicology and teratology,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
August 1988,
Brain research,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
June 2008,
Toxicology,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
August 1978,
Journal of neurocytology,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
January 2003,
Annual review of pharmacology and toxicology,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
February 1963,
Internationale Zeitschrift fur Vitaminforschung. Beiheft,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
March 1962,
Nature,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
September 2002,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
May 1994,
Sangyo igaku. Japanese journal of industrial health,
J Misumi, and
M Nagano, and
J Kaisaku, and
T Hitoshi
January 1989,
Neurotoxicology,
