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Angiotensin-converting enzyme (ACE, E.C. 3.4.15.1) has been identified as a normal constituent of human cerebrospinal fluid (CSF). ACE activity in CSF from adult subjects without known neurologic disorder correlated positively (P = 0.002) with age between 50 and 90 years. Patients with moderate degrees of senile dementia of the Alzheimer's type and comparably demented patients with Parkinson's disease or progressive supranuclear palsy exhibited mean levels of ACE activity that were decreased 41, 27 and 53% respectively, compared to the mean level in an age and sex-matched group of neurologically intact individuals. These results raise the possibility that ACE activity in CSF may be an index of neuronal dysfunction in certain central neurodegenerative disorders.
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
September 1993,
The Japanese journal of psychiatry and neurology,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
January 1998,
Movement disorders : official journal of the Movement Disorder Society,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
October 2015,
Journal of the neurological sciences,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
January 2018,
Journal of Alzheimer's disease : JAD,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
May 1985,
Archives of internal medicine,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
April 1988,
Journal of neurology, neurosurgery, and psychiatry,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
September 1986,
Neurology,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
March 2022,
Molecular medicine reports,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
November 1994,
Clinica chimica acta; international journal of clinical chemistry,
G S Zubenko, and
L Volicer, and
L K Direnfeld, and
M Freeman, and
P J Langlais, and
R A Nixon
February 2004,
Movement disorders : official journal of the Movement Disorder Society,
