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Most of the small number of cases of poliomyelitis which occur in countries where Sabin's attenuated poliovirus vaccines are used are temporally associated with administration of vaccine and involve polioviruses of types 2 and 3 (ref. 1). Recent studies have provided convincing evidence that the Sabin type 2 and 3 viruses themselves may revert to a neurovirulent phenotype on passage in man. We report here that a point mutation in the 5' noncoding region of the genome of the poliovirus type 3 vaccine consistently reverts to wild type in strains isolated from cases of vaccine-associated poliomyelitis. Virus with this change is rapidly selected on passage through the human gastrointestinal tract. The change is associated with a demonstrable increase in the neurovirulence of the virus.
D M Evans, and
G Dunn, and
P D Minor, and
G C Schild, and
A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
December 1999,
Journal of virology,
D M Evans, and
G Dunn, and
P D Minor, and
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A J Cann, and
G Stanway, and
J W Almond, and
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J V Maizel
October 1984,
Nucleic acids research,
D M Evans, and
G Dunn, and
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G C Schild, and
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G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
April 1992,
Journal of virology,
D M Evans, and
G Dunn, and
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A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
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Japanese journal of infectious diseases,
D M Evans, and
G Dunn, and
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G C Schild, and
A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
April 1979,
Journal of biological standardization,
D M Evans, and
G Dunn, and
P D Minor, and
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A J Cann, and
G Stanway, and
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K Currey, and
J V Maizel
July 1976,
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D M Evans, and
G Dunn, and
P D Minor, and
G C Schild, and
A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
June 2016,
BMC infectious diseases,
D M Evans, and
G Dunn, and
P D Minor, and
G C Schild, and
A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
December 1993,
Biologicals : journal of the International Association of Biological Standardization,
D M Evans, and
G Dunn, and
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G C Schild, and
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G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
January 1980,
Journal of biological standardization,
D M Evans, and
G Dunn, and
P D Minor, and
G C Schild, and
A J Cann, and
G Stanway, and
J W Almond, and
K Currey, and
J V Maizel
December 1964,
La Pediatria,
