BIOMAT Database Logo BIOMAT Database Logo

BODIPY-based turn-on fluorescent probes for cysteine and homocysteine. 2018

Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, PR China.

Cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are interconnected and play essential roles in many biological processes. It is significant importance to detect these thiols for investigating their functions in cells and disease diagnosis. In this work, we have designed and synthesized two novel BODIPY-based turn-on fluorescent probes (BDP-Ph and BDP-R-Ph) carrying 4-methoxythiophenol moiety at meso position as good leaving group for highly selective detection of Cys and Hcy. Furthermore, the probes have been successfully applied to detect intracellular Cys and Hcy by fluorescent imaging in living cells.

UI MeSH Term Description Entries
D001896 Boron Compounds Inorganic or organic compounds that contain boron as an integral part of the molecule. Borides,Compounds, Boron
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006710 Homocysteine A thiol-containing amino acid formed by a demethylation of METHIONINE. 2-amino-4-mercaptobutyric acid,Homocysteine, L-Isomer,2 amino 4 mercaptobutyric acid,Homocysteine, L Isomer,L-Isomer Homocysteine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D013050 Spectrometry, Fluorescence Measurement of the intensity and quality of fluorescence. Fluorescence Spectrophotometry,Fluorescence Spectroscopy,Spectrofluorometry,Fluorescence Spectrometry,Spectrophotometry, Fluorescence,Spectroscopy, Fluorescence
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
BODIPY-Based Fluorescent Probes for Biothiols.
April 2020, Chemistry (Weinheim an der Bergstrasse, Germany),
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
"Turn-on" FRET-based luminescent iridium(III) probes for the detection of cysteine and homocysteine.
April 2011, Chemical communications (Cambridge, England),
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
Selective homocysteine turn-on fluorescent probes and their bioimaging applications.
July 2014, Chemical communications (Cambridge, England),
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
BODIPY-based ratiometric fluorescent sensor for highly selective detection of glutathione over cysteine and homocysteine.
November 2012, Journal of the American Chemical Society,
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity.
January 2016, Talanta,
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
A series of BODIPY-based probes for the detection of cysteine and homocysteine in living cells.
April 2019, Talanta,
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
Rhodamine-sugar based turn-on fluorescent probe for the detection of cysteine and homocysteine in water.
November 2010, Chemical communications (Cambridge, England),
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
A New Turn on Fluorescent Probe for Selective Detection of Cysteine/Homocysteine.
September 2015, Journal of fluorescence,
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
Native Chemical Ligation-Based Fluorescent Probes for Cysteine and Aminopeptidase N Using meso-thioester-BODIPY.
September 2021, Chemistry (Weinheim an der Bergstrasse, Germany),
Jinhua Gao, and Yuanfang Tao, and Nannan Wang, and Jinling He, and Jian Zhang, and Weili Zhao
A BODIPY-based 'turn-on' fluorescent probe for hypoxic cell imaging.
September 2015, Chemical communications (Cambridge, England),
Copied contents to your clipboard!