-transparent.png){kind=logo}
Cotton-top tamarins were inoculated with sufficient Epstein-Barr virus to induce multiple tumors in each animal within 14 to 21 days. The tumors consisted of large-cell lymphomas that contained multiple copies of the Epstein-Barr virus genome and generated Epstein-Barr virus-carrying cell lines showing no detectable consistent chromosomal abnormality. Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones. Thus the virus induced multiple transformation events in tamarins in vivo to cause malignant tumors resembling the Epstein-Barr virus-associated lymphomas of patients with organ transplants.
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
June 1988,
Journal of medical virology,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
January 1997,
Chemical immunology,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
July 1982,
Nature,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
August 2001,
Blood,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
May 1989,
Journal of virology,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
July 1978,
Virchows Archiv. A, Pathological anatomy and histology,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
September 1977,
Nature,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
February 1989,
Nihon rinsho. Japanese journal of clinical medicine,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
May 1974,
British medical journal,
M L Cleary, and
M A Epstein, and
S Finerty, and
R F Dorfman, and
G W Bornkamm, and
J K Kirkwood, and
A J Morgan, and
J Sklar
October 1972,
Lancet (London, England),
