-transparent.png){kind=logo}
We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells and normal lymphocytes had monoglycosylceramide and diglycosylceramide as major neutral glycosphingolipids. In one patient, diglycosylceramide was markedly increased. II3NeuAc-LacCer (GM3) and more complex gangliosides were detected in both cells. The most characteristic finding in leukemic cells was the occurrence of a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal lymphocytes and neutrophils. This ganglioside may be due to the induced synthesis in association with malignant transformation.
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
April 2017,
American journal of hematology,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
September 2015,
Rare tumors,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
May 2007,
International journal of cancer,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
January 1983,
Blood,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
November 1989,
Blood,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
July 2009,
Journal of the American Academy of Dermatology,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
April 2012,
Hematology (Amsterdam, Netherlands),
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
September 2004,
Frontiers in bioscience : a journal and virtual library,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
July 2012,
The Gulf journal of oncology,
M Kuriyama, and
K Nomura, and
M Tara, and
H Matsubara, and
A Igata
January 1998,
Ryoikibetsu shokogun shirizu,
