-transparent.png){kind=logo}
Human PHA-stimulated mononuclear cells produce a factor which inhibits synovial cell collagen and non-collagen protein synthesis, whereas it enhances hyaluronic acid (HA) production. Indomethacin (10(-4)-10(-6) M), a cyclo-oxygenase inhibitor, suppresses this effect, suggesting that the mechanism is prostaglandin-mediated. The active material, of apparent molecular weight 12 000-20 000, also displays the properties of the mononuclear cell factor (MCF) previously described by others, since its stimulates collagenase and PGE2 release by the cultured synovial cells. Furthermore, it co-purifies with interleukin 1 (IL 1) as shown by lymphocyte-activating factor activity. This strongly suggests that IL 1 could be responsible for some (or all) the effects observed on MCF-exposed synovial cells. From these data, we deduce the possibility that mononuclear cells may participate in limiting synovial collagen deposition in rheumatoid arthritis.
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
September 1985,
Experimental cell research,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
March 1978,
Clinical and experimental dermatology,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
December 1979,
The Journal of experimental medicine,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
November 1990,
Agents and actions,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
June 1993,
Cardiovascular research,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
September 1981,
Cellular immunology,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
September 1985,
Biochemical and biophysical research communications,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
March 1985,
Collagen and related research,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
May 2000,
The British journal of dermatology,
J P Pujol, and
H Penfornis, and
F Arenzana-Seisdedos, and
J Bocquet, and
J Farjanel, and
A Rattner, and
M Brisset, and
J L Virelizier, and
R Beliard, and
G Loyau
July 1983,
Scandinavian journal of immunology,
