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Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance. 2018
Inna M Yasinska, and
Isabel Gonçalves Silva, and
Svetlana Sakhnevych, and
Bernhard F Gibbs, and
Ulrike Raap, and
Elizaveta Fasler-Kan, and
Vadim V Sumbayev
Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.
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