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In a study of recombinant proteins that might be useful in developing a vaccine against malaria, synthetic peptides from the circumsporozoite (CS) protein of Plasmodium falciparum were found to be immunogenic for mice and rabbits. Antibody to peptides from the repeating region of the CS protein recognized native CS protein and blocked sporozoite invasion of human hepatoma cells in vitro. Antibodies to peptides from regions I and II had no biologic activity, although antibody to region I recognized processed CS protein by Western blot analysis. These data support the feasibility of developing a vaccine against the sporozoite stage of the malaria parasite by using synthetic peptides of the repeating region of the CS protein conjugated to a carrier protein.
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
August 2006,
Experimental parasitology,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
April 1987,
Experimental parasitology,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
January 1998,
Vaccine,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
December 2004,
International journal for parasitology,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
August 2001,
Vaccine,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
August 1990,
Biochemistry,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
November 1989,
Journal of chromatography,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
August 1991,
Journal of molecular biology,
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
July 1989,
Journal of immunology (Baltimore, Md. : 1950),
W R Ballou, and
J Rothbard, and
R A Wirtz, and
D M Gordon, and
J S Williams, and
R W Gore, and
I Schneider, and
M R Hollingdale, and
R L Beaudoin, and
W L Maloy
August 1996,
The Journal of infectious diseases,
