BIOMAT Database Logo BIOMAT Database Logo

Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. 2018

Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.

The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these activities and that fibroblast growth factor receptor-3 (FGFR3) tyrosine kinase binds PV E2. Expression of FGFR3 decreased viral replication with both wild-type and the phenylalanine substitution at position 102, inferring that another kinase targets Y102. Here we tested FGFR- 1, -2 and -4 for association with PV E2 proteins. FGFR2 but not FGFR1 or FGFR4 co-immunoprecipitated with BPV-1 E2. We found that FGFR2 suppressed replication but did not depend on phosphorylation of BPV-1 Y102. HPV-16 and -31 E2 interacted with FGFR1, -2, and -4. These results imply that the expression and activity of FGF receptors in epithelial cells can regulate the function of E2 in viral replication.

UI MeSH Term Description Entries
D010766 Phosphorylation The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. Phosphorylations
D011505 Protein-Tyrosine Kinases Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors. Tyrosine Protein Kinase,Tyrosine-Specific Protein Kinase,Protein-Tyrosine Kinase,Tyrosine Kinase,Tyrosine Protein Kinases,Tyrosine-Specific Protein Kinases,Tyrosylprotein Kinase,Kinase, Protein-Tyrosine,Kinase, Tyrosine,Kinase, Tyrosine Protein,Kinase, Tyrosine-Specific Protein,Kinase, Tyrosylprotein,Kinases, Protein-Tyrosine,Kinases, Tyrosine Protein,Kinases, Tyrosine-Specific Protein,Protein Kinase, Tyrosine-Specific,Protein Kinases, Tyrosine,Protein Kinases, Tyrosine-Specific,Protein Tyrosine Kinase,Protein Tyrosine Kinases,Tyrosine Specific Protein Kinase,Tyrosine Specific Protein Kinases
D004261 DNA Replication The process by which a DNA molecule is duplicated. Autonomous Replication,Replication, Autonomous,Autonomous Replications,DNA Replications,Replication, DNA,Replications, Autonomous,Replications, DNA
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000076662 Host Microbial Interactions Interactions between a host and microbe or microbiota. Host-Bacteria Interactions,Host-Microbe Interactions,Host-Microbial Interactions,Host-Virus Interactions,Microbe-Host Interactions,Microbial-Host Interactions,Microbiota-Host Interactions,Virus-Host Interactions,Bacteria Host Interactions,Bacterial-Host Interactions,Bacterium-Host Interactions,Host Bacteria Interactions,Host Microbe Interactions,Host Microbiota Interactions,Host Virus Interactions,Host-Fungal Interactions,Host-Microbial Interface,Microbe Host Interactions,Microbial Host Interactions,Microbiota Host Interactions,Viral-Host Interactions,Virus Host Interactions,Bacteria Host Interaction,Bacterial Host Interactions,Bacterial-Host Interaction,Bacterium Host Interactions,Bacterium-Host Interaction,Host Bacteria Interaction,Host Fungal Interactions,Host Microbe Interaction,Host Microbial Interaction,Host Microbial Interface,Host Microbiota Interaction,Host Virus Interaction,Host-Bacteria Interaction,Host-Fungal Interaction,Host-Microbe Interaction,Host-Microbial Interaction,Host-Microbial Interfaces,Host-Virus Interaction,Interaction, Host-Bacteria,Interaction, Host-Microbe,Interaction, Host-Microbial,Interaction, Host-Virus,Interaction, Microbe-Host,Interaction, Microbial-Host,Interaction, Microbiota-Host,Interaction, Virus-Host,Interactions, Host-Bacteria,Interactions, Host-Microbe,Interactions, Host-Microbial,Interactions, Host-Virus,Interactions, Microbe-Host,Interactions, Microbial-Host,Interactions, Microbiota-Host,Interactions, Virus-Host,Microbe Host Interaction,Microbe-Host Interaction,Microbial Host Interaction,Microbial-Host Interaction,Microbiota Host Interaction,Microbiota-Host Interaction,Viral Host Interactions,Viral-Host Interaction,Virus Host Interaction,Virus-Host Interaction
D014764 Viral Proteins Proteins found in any species of virus. Gene Products, Viral,Viral Gene Products,Viral Gene Proteins,Viral Protein,Protein, Viral,Proteins, Viral
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D047468 Immunoprecipitation The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution. Co-Immunoprecipitation,Immune Precipitation,Co Immunoprecipitation,Co-Immunoprecipitations,Immune Precipitations,Precipitation, Immune,Precipitations, Immune
D051496 Receptor, Fibroblast Growth Factor, Type 1 A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. Fibroblast Growth Factor Receptor 1,CD331 Antigen,FGFR1 Protein,FGFR1 Tyrosine Kinase,Fibroblast Growth Factor Soluble Receptor 1,fms-Like Tyrosine Kinase-2,Antigen, CD331,fms Like Tyrosine Kinase 2

Related Publications

Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells.
August 1996, Molecular biology of the cell,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Androgen receptor protein is down-regulated by basic fibroblast growth factor in prostate cancer cells.
January 2000, British journal of cancer,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D.
November 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
The stability of the lens-specific Maf protein is regulated by fibroblast growth factor (FGF)/ERK signaling in lens fiber differentiation.
January 2003, The Journal of biological chemistry,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Signal transduction by fibroblast growth factor receptors.
February 1999, Frontiers in bioscience : a journal and virtual library,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Cellular signaling by fibroblast growth factor receptors.
April 2005, Cytokine & growth factor reviews,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
TRX is up-regulated by fibroblast growth factor-2 in lung carcinoma.
January 2011, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics.
January 2004, Development (Cambridge, England),
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor.
April 1994, The Journal of clinical investigation,
Marsha DeSmet, and Sriramana Kanginakudru, and Leny Jose, and Fang Xie, and Timra Gilson, and Elliot J Androphy
Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor.
March 1989, The Journal of biological chemistry,
Copied contents to your clipboard!