-transparent.png){kind=logo}
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
Related Publications
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
October 1984,
The Journal of biological chemistry,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
January 1988,
Biochimica et biophysica acta,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
September 1983,
Proceedings of the National Academy of Sciences of the United States of America,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
June 1990,
European journal of pharmacology,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
January 1990,
Biokhimiia (Moscow, Russia),
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
February 1966,
Biochimica et biophysica acta,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
December 1987,
Journal of neurochemistry,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
June 1985,
Thrombosis research,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
November 1990,
Cell regulation,
S M Chung, and
A D Proia, and
G K Klintworth, and
S P Watson, and
E G Lapetina
April 1988,
Thrombosis and haemostasis,
