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In the present work we have been able to demonstrate that phenobarbital and lead exert an inducing effect on the biosynthesis of delta-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450 hemoproteins in isolated rat hepatocytes of normal adult rats. Dibutyryl cyclic AMP enhances the induction effect produced by phenobarbital in this in vitro system. Glucose inhibits the induction of delta-aminolevulinic acid synthase and ferrochelatase. This repression effect can be reversed with increasing concentrations of dibutyryl cyclic AMP. No glucose effect was observed on the phenobarbital- and lead-mediated inductions of cytochrome P-450. he present results add more experimental evidence to support the concept that the last enzyme of the heme pathway is inducible, and as such may have a significant role in regulatory mechanisms of porphyrin and heme biosynthesis.
E T Cánepa, and
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M Grinstein
November 1981,
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E T Cánepa, and
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M Grinstein
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E T Cánepa, and
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M Grinstein
January 1988,
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E T Cánepa, and
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M Grinstein
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E T Cánepa, and
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M Grinstein
September 1976,
Science (New York, N.Y.),
E T Cánepa, and
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M Grinstein
September 1990,
Cancer research,
E T Cánepa, and
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E T Cánepa, and
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M Grinstein
January 1978,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
E T Cánepa, and
E B Llambías, and
M Grinstein
October 1981,
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E T Cánepa, and
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