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Sera from 50 Japanese hemophiliacs were screened for antibodies to human T-lymphotropic retrovirus types I and III (HTLV-I and -III). As a whole, antibody to HTLV-I, antibody to HTLV-III, and antibodies to HTLV-I and -III were detected in sera from 2, 17, and 6 hemophiliacs, respectively. Among them, two hemophiliacs developed acquired immunodeficiency syndrome who were positive for both antibodies to HTLV-I and -III in sera. All of the others were asymptomatic. Most of the blood products transfused into these hemophiliacs were imported from abroad, whence the source of HTLV-III infection presumably originated. However, since quite a high percentage of these antibody-positive hemophiliacs was positive for antibody to HTLV-I, even though they are native residents in HTLV-I nonendemic areas of Japan, some special factors may have participated in HTLV-I infection. These special factors should be investigated in the future.
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
December 1986,
AIDS research,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
September 1985,
Blood,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
December 1985,
Thrombosis and haemostasis,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
October 1984,
Lancet (London, England),
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
January 1983,
AIDS research,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
June 1986,
JAMA,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
April 1986,
Medicina clinica,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
January 1987,
Acta haematologica,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
May 1986,
Clinical chemistry,
T Abe, and
T Kinoshita, and
J Matsuda, and
T Ryu, and
R C Ting, and
T Aoki, and
M Robert-Guroff, and
H Miyakoshi, and
R C Gallo
December 1984,
The New England journal of medicine,
