Biomaterial Database

Reduction and oxidation of cytochrome C by Hymenolepis diminuta (Cestoda) mitochondria. 1985

Y Kim, and C F Fioravanti

Mitochondrial membranes of adult Hymenolepis diminuta catalyzed inhibitor-sensitive ferricytochrome c reduction. Cytochrome c reductase activity was noted when NAD(P)H or succinate served as the reductant with the NADH-coupled reaction being most prominent. Both rotenone-sensitive and -insensitive reduced pyridine nucleotide-coupled activities were apparent. Ferrocytochrome c oxidase activity also was catalyzed by H. diminuta mitochondrial membranes and this reaction was sensitive to azide and cyanide. A cytochrome c peroxidase activity was associated primarily with the mitochondrial soluble fraction of adult H. diminuta. The possibility that the activities observed may contribute to the elimination of peroxide in the helminth system is considered.

UI	MeSH Term	Description	Entries
D008928	Mitochondria	Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)	Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D011190	Potassium Cyanide	A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.	Potassium Cyanide (K(14)CN),Potassium Cyanide (K(C(15)N)),Cyanide, Potassium
D003574	Cytochrome c Group	A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)	Cytochromes Type c,Group, Cytochrome c,Type c, Cytochromes
D006926	Hymenolepis	A genus of small tapeworms of birds and mammals.	Hymenolepi
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000968	Antimycin A	An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed)	Butanoic acid, 2(or 3)-methyl-, 3-((3-(formylamino)-2-hydroxybenzoyl)amino)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester,Antimycin A1
D001386	Azides	Organic or inorganic compounds that contain the -N3 group.	Azide
D012402	Rotenone	A botanical insecticide that is an inhibitor of mitochondrial electron transport.
D019810	Sodium Azide	A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)	NaN3,Azide, Sodium