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The role of central vs. peripheral actions of clonidine was investigated in the rat following the separate and combined administration of clonidine and 2-deoxy-D-glucose (2-DG). Clonidine or 2-DG alone stimulated serum glucose and corticosterone but hypothalamic noradrenaline neuronal activity and ACTH release were stimulated by 2-DG only. The stimulation of noradrenaline neuronal activity and ACTH by 2-DG were totally blocked by clonidine. It was concluded that the increases in serum glucose and corticosterone after clonidine administration were not mediated by central effects but that alpha 2-adrenoceptor agonism by clonidine was responsible for inhibition of hypothalamic noradrenaline neuronal activity and pituitary ACTH release.
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
March 1984,
Clinical pharmacology and therapeutics,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
December 1969,
Endocrinology,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
February 1987,
Neuroendocrinology,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
July 1986,
Hypertension (Dallas, Tex. : 1979),
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
September 1985,
Life sciences,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
March 1972,
European journal of clinical pharmacology,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
September 1993,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
January 1991,
Annals of the New York Academy of Sciences,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
November 1992,
Research communications in chemical pathology and pharmacology,
G A Smythe, and
J E Bradshaw, and
R M Gleeson, and
H S Grunstein, and
M V Nicholson
February 2008,
Neuro endocrinology letters,
