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Four classes of non-mammalian vertebrates were examined for the presence of both 'brain-specific' and 'peripheral-type' binding sites for benzodiazepines in the central nervous system. 'Brain-specific' binding sites for benzodiazepines were found in the central nervous systems of all non-mammalian vertebrates studied. However, in contrast to mammals, either very low or undetectable levels of 'peripheral-type' binding sites for benzodiazepines were observed in the central nervous systems of these non-mammalian vertebrates. Furthermore, the density of 'peripheral-type' binding sites for benzodiazepines in non-mammalian vertebrate heart was less than or equal to 2% of that found in mammalian cardiac tissue. These findings suggest a very late evolutionary appearance of 'peripheral-type' binding sites for benzodiazepines, implying that these sites may have (a) highly specialized function(s) in both peripheral tissues and the central nervous system.
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
January 1992,
Journal of basic and clinical physiology and pharmacology,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
December 1984,
Pharmacology, biochemistry, and behavior,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
January 1986,
Journal of neurochemistry,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
May 1984,
Molecular pharmacology,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
March 1985,
European journal of pharmacology,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
January 1985,
Progress in clinical and biological research,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
September 1986,
The Journal of pharmacology and experimental therapeutics,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
January 1985,
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
January 1985,
Progress in clinical and biological research,
G T Bolger, and
B A Weissman, and
H Lueddens, and
A S Basile, and
C R Mantione, and
J E Barrett, and
J M Witkin, and
S M Paul, and
P Skolnick
October 1984,
FEBS letters,
