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Plasma corticotrophin (ACTH), cortisol, prolactin and growth hormone (GH) responses to insulin-induced hypoglycaemia were measured in normal healthy subjects of both sexes before and after three weeks' treatment with sodium valproate (Epilim, 200 mg three times a day). The drug had no effect on fasting plasma glucose levels, or the extent of hypoglycaemia induced by insulin (0.15 U/kg). There was no significant difference between pre- and post-treatment values for basal or stress-induced concentrations of ACTH and cortisol (n = 12), prolactin (n = 7) or GH (n = 9). The results suggest that treatment of normal subjects with sodium valproate has no effect on the response of the hypothalamo-pituitary-adrenocortical axis to hypoglycaemia, which is in contrast to its inhibitory effects on ACTH secretion in patients suffering from Nelson's syndrome. This implies that in the disease state, there may be a unique sensitivity to GABA-ergic manipulation.
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
January 1974,
East African medical journal,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
June 1980,
Clinical endocrinology,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
March 1978,
British medical journal,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
February 1977,
Acta endocrinologica,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
January 1982,
British medical journal (Clinical research ed.),
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
June 1982,
British medical journal (Clinical research ed.),
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
December 1972,
Lancet (London, England),
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
June 1975,
European journal of clinical investigation,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
April 1971,
The Journal of clinical endocrinology and metabolism,
R R Abraham, and
A Dornhorst, and
V Wynn, and
A R Altaher, and
E A Campbell, and
U Beckford, and
S M Watts, and
S A Nicholson, and
B Gillham, and
A Thody
April 1981,
The Journal of clinical endocrinology and metabolism,
