BIOMAT Database Logo BIOMAT Database Logo

Farletuzumab, a monoclonal antibody directed against folate receptor alpha, shows no evidence of teratogenicity in cynomolgus monkeys. 2018

Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Eisai Inc., 4 Corporate Dr., Andover, MA 01810, USA. Electronic address: tomoyuki_moriyama@eisai.com.

Farletuzumab is a humanized monoclonal antibody targeting human folate receptor alpha, which is being developed as an anti-cancer drug. A non-human primate reproductive study was conducted to evaluate whether it could cause any embryonic or fetal abnormalities. Farletuzumab was administered intravenously to pregnant cynomolgus monkeys (n = 16/group) at doses of 0 or 67.5 mg/kg once weekly during gestation day (GD) 20 through 97. C-section was performed on GD100 ± 2, and fetuses were evaluated for morphologic (external, visceral and skeletal) effects. No farletuzumab-related changes were observed in maternal animals or fetuses, which are supported by the fact that farletuzumab has no effects on cellular uptake of folate. These data support the potential use of farletuzumab for oncologic indications during pregnancy.

UI MeSH Term Description Entries
D008252 Macaca fascicularis A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula. Burmese Long-Tailed Macaque,Crab-Eating Monkey,Cynomolgus Monkey,M. f. aurea,M. fascicularis,Macaca fascicularis aurea,Monkey, Crab-Eating,Monkey, Cynomolgus,Crab-Eating Macaque,Burmese Long Tailed Macaque,Crab Eating Macaque,Crab Eating Monkey,Crab-Eating Macaques,Crab-Eating Monkeys,Cynomolgus Monkeys,Long-Tailed Macaque, Burmese,Macaque, Burmese Long-Tailed,Macaque, Crab-Eating,Monkey, Crab Eating
D008297 Male Males
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D047108 Embryonic Development Morphological and physiological development of EMBRYOS. Embryo Development,Embryogenesis,Postimplantation Embryo Development,Preimplantation Embryo Development,Embryonic Programming,Post-implantation Embryo Development,Postnidation Embryo Development,Postnidation Embryo Development, Animal,Pre-implantation Embryo Development,Prenidation Embryo Development, Animal,Development, Embryo,Development, Embryonic,Development, Postnidation Embryo,Embryo Development, Post-implantation,Embryo Development, Postimplantation,Embryo Development, Postnidation,Embryo Development, Pre-implantation,Embryo Development, Preimplantation,Embryonic Developments,Embryonic Programmings,Post implantation Embryo Development,Pre implantation Embryo Development
D047109 Fetal Development Morphological and physiological development of FETUSES. Fetal Programming,Fetal Growth,Development, Fetal,Fetal Programmings,Growth, Fetal

Related Publications

Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.
June 2013, Gynecologic oncology,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer.
November 2012, Cancer chemotherapy and pharmacology,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study.
November 2010, Clinical cancer research : an official journal of the American Association for Cancer Research,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator.
December 2009, Reproductive toxicology (Elmsford, N.Y.),
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
A phase I study of farletuzumab, a humanized anti-folate receptor α monoclonal antibody, in patients with solid tumors.
April 2015, Investigational new drugs,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety.
September 2014, Toxicology and applied pharmacology,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Importance of cynomolgus monkeys in development of monoclonal antibody drugs.
February 2019, Drug metabolism and pharmacokinetics,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.
July 1999, Neuroscience letters,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application.
December 2021, Drug delivery,
Tomoyuki Moriyama, and Dai Kakiuchi, and Luigi Grasso, and David L Hutto, and Danielle Fernando, and Charles Schweizer
Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha.
March 2007, Cancer immunity,
Copied contents to your clipboard!