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Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. 2018
Jonathan Miller, and
Andrew J Watrous, and
Melina Tsitsiklis, and
Sang Ah Lee, and
Sameer A Sheth, and
Catherine A Schevon, and
Elliot H Smith, and
Michael R Sperling, and
Ashwini Sharan, and
Ali Akbar Asadi-Pooya, and
Gregory A Worrell, and
Stephen Meisenhelter, and
Cory S Inman, and
Kathryn A Davis, and
Bradley Lega, and
Paul A Wanda, and
Sandhitsu R Das, and
Joel M Stein, and
Richard Gorniak, and
Joshua Jacobs
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY, 10027, USA.
The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1-3-Hz "low theta" band increases when viewing subsequently remembered object-location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.
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