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Isoproterenol, prostaglandin E1 and forskolin-stimulated cyclic AMP accumulation were compared in intact lymphocytes obtained from nine monozygotic and nine sib pairs matched for age and sex. Heritability was calculated by three different methods, two based on the intraclass correlation coefficients and one based directly on the variances. Only for forskolin is a significant proportion of variance (0.68-0.91) attributable to genetic factors, suggesting that forskolin-stimulated activity may prove to be a valuable genetic marker in studies of human pathology. Neither basal nor isoproterenol and prostaglandin E1-stimulated activity show significant heritability in intact human lymphocytes. The individual differences observed in levels of beta-adrenergic and prostaglandin stimulated receptor activity in human lymphocytes are, therefore, most likely due to environmental factors.
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
January 1984,
Neuropsychobiology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
March 1986,
Molecular pharmacology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
April 1987,
European journal of pharmacology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
December 1986,
American journal of obstetrics and gynecology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
August 1982,
Life sciences,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
December 1985,
European journal of pharmacology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
April 1983,
FEBS letters,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
November 1989,
Chemical & pharmaceutical bulletin,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
January 1986,
Experimental gerontology,
J Stessmann, and
J Mintzer, and
Y Lipschitz, and
Z Shemesh, and
L R Goldin, and
R P Ebstein
June 1983,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
