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Receptors for the dihydropyridine class of Ca2+ channel antagonists are present on transverse tubules isolated by mechanical disruption of skeletal muscle triads. These observations account for the previously reported presence of nitrendipine binding sites in heavy sarcoplasmic reticulum. Nitrendipine receptors were not found in the terminal cisternae after disruption of the triad junctions. The number of sites in junctional T-tubules (27 pmol/mg) is only half that reported for transverse tubules isolated as free vesicles (pmol/mg). The presence of nitrendipine receptors in that region of the transverse tubules held in close apposition to the SR cisternae is consistent with the architectural requirements for the Ca2+ induced Ca2+ release phenomenon to be the mechanism of excitation-contraction coupling.
N R Brandt, and
R M Kawamoto, and
A H Caswell
January 1988,
Archives of biochemistry and biophysics,
N R Brandt, and
R M Kawamoto, and
A H Caswell
January 1986,
Biochimica et biophysica acta,
N R Brandt, and
R M Kawamoto, and
A H Caswell
July 1993,
The Journal of biological chemistry,
N R Brandt, and
R M Kawamoto, and
A H Caswell
February 2002,
The Journal of membrane biology,
N R Brandt, and
R M Kawamoto, and
A H Caswell
October 1995,
Journal of muscle research and cell motility,
N R Brandt, and
R M Kawamoto, and
A H Caswell
January 1991,
The Journal of cell biology,
N R Brandt, and
R M Kawamoto, and
A H Caswell
August 1984,
Biochemical and biophysical research communications,
N R Brandt, and
R M Kawamoto, and
A H Caswell
January 1989,
Biochimica et biophysica acta,
N R Brandt, and
R M Kawamoto, and
A H Caswell
February 1986,
Biochimica et biophysica acta,
N R Brandt, and
R M Kawamoto, and
A H Caswell
December 1993,
Annals of the New York Academy of Sciences,
