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The role of clinical and molecular factors in low-grade gliomas: what is their impact on survival? 2018
Enrico Franceschi, and
Antonella Mura, and
Dario De Biase, and
Giovanni Tallini, and
Annalisa Pession, and
Maria Pia Foschini, and
Daniela Danieli, and
Stefano Pizzolitto, and
Elena Zunarelli, and
Giovanni Lanza, and
Daniela Bartolini, and
Enrico Maria Silini, and
Michela Visani, and
Enrico Di Oto, and
Alicia Tosoni, and
Santino Minichillo, and
Giuseppe Lamberti, and
Andrea Lanese, and
Alexandro Paccapelo, and
Stefania Bartolini, and
Alba A Brandes
Department of Medical Oncology, Bellaria-Maggiore Hospitals, Azienda USL, IRCCS Institute of Neurological Sciences, Bologna, Italy.
OBJECTIVE To evaluate relevance of clinical and molecular factors in adult low-grade gliomas (LGG) and to correlate with survival. METHODS We reviewed records from adult LGG patients from 1991 to 2015 who received surgery and had sufficient tissue to molecular biomarkers characterization. RESULTS 213 consecutive LGG patients were included: 17.4% were low-risk, according to Radiation Therapy Oncology Group (RTOG) risk assessment. IDH 1/2 mutation, 1p/19q co-deletion, MGMT methylation were found in 93, 50.8 and 65.3% of patients. Median follow-up was 98.3 months. In univariate analysis, overall survival was influenced by extent of resection (p = 0.011), IDH mutation (p < 0.001), 1p/19q co-deletion (p = 0.015) and MGMT methylation (p = 0.013). In multivariate analysis, RTOG clinical risk (p = 0.006), IDH mutation (p < 0.001) and 1p/19q co-deletion (p = 0.035) correlated with overall survival. RTOG clinical risk (p = 0.006), IDH mutation (p < 0.001) and 1p/19q co-deletion (p = 0.035) correlated with overall survival. CONCLUSIONS Both clinical and molecular factors are essential to determine prognosis and treatment strategies.
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