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The effect of some reductones such as ascorbic acid (AsA), triose reductone (TR), epinephrine (Ep) and their derivatives on cyclic 3', 5'-adenosine monophosphate phosphodiesterase (cAMP PDE) was studied in the presence or absence of Cu2+. AsA, TR, Ep and the reductones related to them inhibited cAMP PDE activity. Among the reductones, TR showed the highest inhibition. AsA, 5-methyl-3,4-dihydroxytetrone, pyrocatechol, p-hydroxyquinone and resorcinol had a relatively high inhibiting activity. The type of inhibition of AsA, TR and Ep was uncompetitive, competitive and noncompetitive, respectively. Cu2+ enhanced the inhibitory action of the reductones markedly and altered the type of inhibition of the reductones.
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
January 1973,
Biochemical pharmacology,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
December 1970,
The Biochemical journal,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
July 1972,
Proceedings of the National Academy of Sciences of the United States of America,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
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H Omura
November 1973,
Journal of bacteriology,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
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H Omura
November 1970,
The Biochemical journal,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
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H Omura
August 1974,
Biochemical pharmacology,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
January 1975,
Cancer research,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
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H Murakami, and
H Omura
February 1983,
The Journal of antibiotics,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
July 1975,
The Journal of antibiotics,
K Shinohara, and
H Fujiki, and
Y Hidaka, and
Y K Tseng, and
H Murakami, and
H Omura
June 1975,
Journal of bacteriology,
