BIOMAT Database Logo BIOMAT Database Logo

Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster. 2019

Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.

Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that aging has an important genetic component. Animal species age at different rates and specific signaling pathways, such as insulin/insulin-like growth factor, can regulate life span of individuals within a species by reprogramming cells in response to environmental changes. Here, we use an unbiased approach to identify novel factors that regulate life span in Drosophila melanogaster. We compare the transcriptome and metabolome of two wild-type strains used widely in aging research: short-lived Dahomey and long-lived Oregon R flies. We found that Dahomey flies carry several traits associated with short-lived individuals and species such as increased lipoxidative stress, decreased mitochondrial gene expression, and increased Target of Rapamycin signaling. Dahomey flies also have upregulated octopamine signaling known to stimulate foraging behavior. Accordingly, we present evidence that increased foraging behavior, under laboratory conditions where nutrients are in excess increases damage generation and accelerates aging. In summary, we have identified several new pathways, which influence longevity highlighting the contribution and importance of the genetic component of aging.

UI MeSH Term Description Entries
D008136 Longevity The normal length of time of an organism's life. Length of Life,Life Span,Lifespan,Life Spans,Lifespans
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D015870 Gene Expression The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. Expression, Gene,Expressions, Gene,Gene Expressions
D055442 Metabolome The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions. Metabolic Profile,Metabolic Profiles,Metabolomes,Profile, Metabolic,Profiles, Metabolic
D059467 Transcriptome The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells. Transcriptomes,Gene Expression Profiles,Gene Expression Signatures,Transcriptome Profiles,Expression Profile, Gene,Expression Profiles, Gene,Expression Signature, Gene,Expression Signatures, Gene,Gene Expression Profile,Gene Expression Signature,Profile, Gene Expression,Profile, Transcriptome,Profiles, Gene Expression,Profiles, Transcriptome,Signature, Gene Expression,Signatures, Gene Expression,Transcriptome Profile
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative

Related Publications

Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Enzymatic differences between short-lived and long-lived Drosophila strains.
January 1975, Advances in experimental medicine and biology,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Patterns of amino acid incorporation in long-lived genetic strains of Drosophila melanogaster.
January 1989, Experimental gerontology,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster.
March 2001, Experimental gerontology,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
The metabolic profile of long-lived Drosophila melanogaster.
January 2012, PloS one,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Antigenic differences between mutant strains of Drosophila melanogaster.
January 1948, Genetics,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Testing the 'free radical theory of aging' hypothesis: physiological differences in long-lived and short-lived colubrid snakes.
June 2007, Aging cell,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Long-lived genotypes for studies of life extension in Drosophila melanogaster.
May 2012, Mechanisms of ageing and development,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Metabolic rates in genetically based long lived strains of Drosophila.
January 1988, Experimental gerontology,
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Selected contribution: long-lived Drosophila melanogaster lines exhibit normal metabolic rates.
December 2003, Journal of applied physiology (Bethesda, Md. : 1985),
Nina Gubina, and Alba Naudi, and Rhoda Stefanatos, and Mariona Jove, and Filippo Scialo, and Daniel J Fernandez-Ayala, and Tommi Rantapero, and Ihor Yurkevych, and Manuel Portero-Otin, and Matti Nykter, and Oleh Lushchak, and Placido Navas, and Reinald Pamplona, and Alberto Sanz
Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster.
July 1981, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!