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As part of a programme to assess the para-endocrine behaviour of human infiltrating ductal breast carcinoma among Chinese women, this study was designed to compare (Mann-Whitney U test) the immunoreactive mammary tumour tissue concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), human chorionic gonadotrophin (beta-hCG) and prolaction (PRL) at stages I (n = 9), II (n = 12) and III (n = 7) with that of normal breast tissue (n = 8). It was found that with the exception of FSH and beta-hCG in stages I and III significantly elevated concentrations of protein hormones were noted at all stages of malignancy. The possible importance of these findings in multi-stage mammary carcinogenesis is discussed. It is suggested that measurement of LH concentration may provide an endocrine basis to facilitate the diagnosis of tumours to serve as a guide to the biological behaviour of mammary neoplasms.
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
March 1997,
Cancer research,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
December 1987,
Metabolism: clinical and experimental,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
January 1985,
Nature,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
January 1971,
Problemy endokrinologii,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
February 2007,
Clinical breast cancer,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
January 1988,
Cancer treatment and research,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
June 1990,
Harefuah,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
November 2009,
Expert opinion on pharmacotherapy,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
April 1970,
The Journal of clinical endocrinology and metabolism,
R Gunasegaram, and
K L Peh, and
A Loganath, and
L C Ang, and
D Thiagaraj, and
S R Kottegoda, and
S S Ratnam
January 2000,
Breast cancer research : BCR,
