-transparent.png){kind=logo}
The effects of fluoride on ROS phosphodiesterase and G-protein have been studied using membrane-free extracts. When G-protein was present NaF, at millimolar concentrations, stimulated PDE activity however, in a G-protein free extract, cGMP hydrolysis was inhibited by high fluoride concentrations. Fluoride was also found to profoundly inhibit the ability of G-protein to bind a GTP analogue, GTP gamma S, both in the presence and absence of rhodopsin. Aluminium greatly modified these effects of fluoride on PDE and G-protein. The possibility that fluoride activates PDE through its effect on G-protein is discussed.
Related Publications
N J Cook, and
G Nullans, and
N Virmaux
January 1980,
Biochemical and biophysical research communications,
N J Cook, and
G Nullans, and
N Virmaux
June 1994,
The Journal of biological chemistry,
N J Cook, and
G Nullans, and
N Virmaux
March 1985,
Biochemistry,
N J Cook, and
G Nullans, and
N Virmaux
January 1980,
Doklady Akademii nauk SSSR,
N J Cook, and
G Nullans, and
N Virmaux
January 1988,
Methods in enzymology,
N J Cook, and
G Nullans, and
N Virmaux
June 1982,
The Journal of biological chemistry,
N J Cook, and
G Nullans, and
N Virmaux
March 1990,
Biochemistry,
N J Cook, and
G Nullans, and
N Virmaux
February 2023,
Trends in biochemical sciences,
N J Cook, and
G Nullans, and
N Virmaux
November 1990,
The Journal of biological chemistry,
N J Cook, and
G Nullans, and
N Virmaux
January 1984,
Advances in cyclic nucleotide and protein phosphorylation research,
