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Aqueous extracts of human luteal tissue significantly inhibited binding of 125I-labelled human luteinizing hormone (LH) to the 2,000-g subcellular fraction of human corpora lutea. In contrast, aqueous extract of nonluteal tissue of the human ovary did not show a comparable activity to inhibit LH binding. Extracts of human corpus luteum had little or no ability to inhibit LH binding to porcine luteal homogenates. The inhibitory effect of the aqueous extract on LH binding to human luteal homogenate was demonstrated to be dose-related. The inhibitory effect of aqueous extracts of human corpora lutea on LH binding increased from the early to mid and late luteal phase of the menstrual cycle. The results of the present study suggest that there is an LH receptor binding inhibitor (LHRBI) in the 30,000-g aqueous extract of the human corpus luteum and the increase in LHRBI in the luteal tissue as the human corpus luteum ages may explain the means whereby the human corpus luteum regulates its own life span.
R Nakano, and
M Iwasaki, and
M Yamoto
January 1980,
Hormone research,
R Nakano, and
M Iwasaki, and
M Yamoto
September 1992,
Molecular and cellular endocrinology,
R Nakano, and
M Iwasaki, and
M Yamoto
October 1976,
Acta endocrinologica,
R Nakano, and
M Iwasaki, and
M Yamoto
April 1981,
Environmental health perspectives,
R Nakano, and
M Iwasaki, and
M Yamoto
July 1973,
The Journal of biological chemistry,
R Nakano, and
M Iwasaki, and
M Yamoto
October 1996,
Human reproduction (Oxford, England),
R Nakano, and
M Iwasaki, and
M Yamoto
October 2000,
Gynecologie, obstetrique & fertilite,
R Nakano, and
M Iwasaki, and
M Yamoto
May 1997,
Human reproduction (Oxford, England),
R Nakano, and
M Iwasaki, and
M Yamoto
October 1912,
Texas medical journal (Austin, Tex.),
R Nakano, and
M Iwasaki, and
M Yamoto
March 1989,
The Journal of clinical endocrinology and metabolism,
