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Hepatocytes from fasted rats were used to study the effect of glucagon on intracellular free cytosolic Ca2+ ([Ca2+]i) indicated by the use of Quin-2-calcium fluorescence. It was found that, in both male and female rats, glucagon increased [Ca2+]i at a half-maximally effective concentration (Kact) of 0.3 nM, a concentration known to be half-maximal for affecting several hepatic functions. Acute chelation of extracellular Ca2+ did not obliterate the hormone effect but shortened its duration. Cyclic AMP, 5'-AMP, ADP, and ATP also increased [Ca2+]i, while adenosine 2':3'-monophosphate and 3'-AMP did not. The rise in [Ca2+]i brought about by glucagon at near physiological concentrations may be responsible for the stimulation of glutamate metabolism produced acutely by glucagon.
F D Sistare, and
R A Picking, and
R C Haynes
July 1983,
The Journal of biological chemistry,
F D Sistare, and
R A Picking, and
R C Haynes
August 1991,
The Journal of pharmacology and experimental therapeutics,
F D Sistare, and
R A Picking, and
R C Haynes
December 1984,
Circulation research,
F D Sistare, and
R A Picking, and
R C Haynes
April 1994,
Microcirculation (New York, N.Y. : 1994),
F D Sistare, and
R A Picking, and
R C Haynes
August 1991,
The Journal of pharmacology and experimental therapeutics,
F D Sistare, and
R A Picking, and
R C Haynes
July 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
F D Sistare, and
R A Picking, and
R C Haynes
August 2010,
IDrugs : the investigational drugs journal,
F D Sistare, and
R A Picking, and
R C Haynes
November 2000,
British journal of pharmacology,
F D Sistare, and
R A Picking, and
R C Haynes
May 1970,
Canadian journal of biochemistry,
F D Sistare, and
R A Picking, and
R C Haynes
January 1980,
Nucleic acids symposium series,
