Case reports on dangerous infectious diseases: a review of patient consent. 2020

Kieran Walsh

Case reports are commonly used to describe new infectious diseases. In the past 20 years, there have been an increasing number of emerging infectious diseases that could constitute a major threat to global health security (through naturally occurring pandemics or deliberate release of infectious agents). It is vitally important that case reports related to infectious diseases are written up according to the highest possible standards and that guidelines regarding patient consent to publish are followed. So, do case reports that relate to dangerous infectious diseases follow guidance related to patient consent? To help find the answer to this question, I looked at a sample of case reports published on PubMed between 1 January 2014 and 31 December 2016. I searched for freely available full-text reports of infections that affected humans. The search was conducted for case reports on infectious diseases that pose the greatest risk to global health-infections that have been classified as Tier 1 agents by the Centers for Disease Control and Prevention. An assessment was carried out as to whether the identified case reports satisfied the criteria related to consent as outlined in the CARE guidelines. In total, 71 case reports were found. These were related to Ebola, Botulism, Yersinia and Tularaemia. The authors stated that they had obtained consent to publish in 17 of these case reports. Only a minority of published case reports on extremely dangerous pathogens contain documented evidence that consent was obtained from the patient in question. In this sample, 24% of case reports contained such evidence regarding consent.

UI MeSH Term Description Entries
D007258 Informed Consent Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment. Consent, Informed
D011643 Publishing "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing. Electronic Publishing,Publishing, Electronic,Electronic Publishings,Publishings, Electronic
D001906 Botulism A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208) Botulism, Infantile,Botulism, Toxico-Infectious,Clostridium botulinum Infection,Foodborne Botulism,Infant Botulism,Toxico-Infectious Botulism,Wound Botulism,Botulism, Foodborne,Botulism, Infant,Botulism, Toxico Infectious,Botulism, Wound,Clostridium botulinum Infections,Foodborne Botulisms,Infant Botulisms,Infantile Botulism,Infection, Clostridium botulinum,Toxico Infectious Botulism,Wound Botulisms
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014406 Tularemia A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness. Francisella tularensis Infection,Francisella tularensis Infections,Infection, Francisella tularensis,Tularemias
D015009 Yersinia Infections Infections with bacteria of the genus YERSINIA. Yersinia Infection,Infections, Yersinia,Yersinia enterocolitica Infection,Yersiniosis,Infection, Yersinia,Yersinia enterocolitica Infections,Yersinioses
D019142 Hemorrhagic Fever, Ebola A highly fatal, acute hemorrhagic fever caused by EBOLAVIRUS. Ebola Hemorrhagic Fever,Ebola Virus Disease,Ebolavirus Infection,Ebola Infection,Ebola Virus Infection,Ebolavirus Infections,Infection, Ebola,Infection, Ebola Virus,Infection, Ebolavirus,Infections, Ebolavirus,Virus Infection, Ebola
D021821 Communicable Diseases, Emerging Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode. Infectious Diseases, Emerging,Communicable Diseases, Re-Emerging,Communicable Diseases, Reemerging,Infectious Diseases, Re-Emerging,Infectious Diseases, Reemerging,Communicable Disease, Emerging,Communicable Disease, Re-Emerging,Communicable Disease, Reemerging,Communicable Diseases, Re Emerging,Disease, Emerging Communicable,Disease, Emerging Infectious,Disease, Re-Emerging Communicable,Disease, Re-Emerging Infectious,Disease, Reemerging Communicable,Disease, Reemerging Infectious,Diseases, Emerging Communicable,Diseases, Emerging Infectious,Diseases, Re-Emerging Communicable,Diseases, Re-Emerging Infectious,Diseases, Reemerging Communicable,Diseases, Reemerging Infectious,Emerging Communicable Disease,Emerging Communicable Diseases,Emerging Infectious Disease,Emerging Infectious Diseases,Infectious Disease, Emerging,Infectious Disease, Re-Emerging,Infectious Disease, Reemerging,Infectious Diseases, Re Emerging,Re-Emerging Communicable Disease,Re-Emerging Communicable Diseases,Re-Emerging Infectious Disease,Re-Emerging Infectious Diseases,Reemerging Communicable Disease,Reemerging Communicable Diseases,Reemerging Infectious Disease,Reemerging Infectious Diseases
D035843 Biomedical Research Research that involves the application of the natural sciences, especially biology and physiology, to medicine. Medical Research,Experimental Medicine,Investigational Medicine,Investigative Medicine,Research, Biomedical,Research, Medical,Medicine, Experimental,Medicine, Investigational,Medicine, Investigative

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