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A translocation between chromosomes 3 and 8, t(3;8)(p14.2;q24.13), has been reported in a family with hereditary renal cell carcinoma. Using somatic cell hybrids, we have isolated, separately, both derivative chromosomes. We find that the c-myc oncogene (8q24.1) has been translocated to the derivative 3 [der(3)]. We have not detected a rearrangement within an approximately equal to 21-kilobase region around the c-myc gene using restriction enzyme digestion and Southern blot hybridization analysis. The translocated c-myc gene should provide a probe to the chromosome 3p14 region, which appears to be important not only in renal cell carcinoma but also in small cell carcinoma of the lung. These hybrids have also been useful for the regional mapping of the Chinese hamster ovary cell Gly-B defect to 8q22.1----q24.13 and support the regional assignment of acylase I to 3p21.
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
September 1979,
The New England journal of medicine,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
April 2014,
Cancer genetics,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
January 1996,
Cytogenetics and cell genetics,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
March 1988,
Cancer genetics and cytogenetics,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
February 2003,
Human genetics,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
July 1993,
Cancer research,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
September 1993,
Proceedings of the National Academy of Sciences of the United States of America,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
August 1998,
Proceedings of the National Academy of Sciences of the United States of America,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
April 1984,
Cancer genetics and cytogenetics,
H A Drabkin, and
C Bradley, and
I Hart, and
J Bleskan, and
F P Li, and
D Patterson
October 1996,
Journal of virology,
