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A complete genomic DNA library was prepared from a Chinese hamster-human cell hybrid that contains human chromosome 5 as its only human DNA. Unique or low-copy DNA fragments, isolated form recombinant bacteriophage that contained human DNA inserts, were regionally mapped on chromosome 5 using Southern blot analysis of genomic DNA from a series of hybrid cell lines that were selected as having deletions of various portions of 5q. The chromosome 5-specific DNA library, together with a genetic selective procedure allowing the isolation of hybrid cell lines with deletions of virtually any portion of 5q, will provide a means to construct very accurate physical and recombinational maps of this human chromosome. This system represents an excellent opportunity to examine very precisely the relationship between physical and genetic distances for many loci along the length of this autosome.
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
January 1996,
Oncogene,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
November 1991,
Genomics,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
December 2006,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
January 1987,
Birth defects original article series,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
October 1988,
American journal of human genetics,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
January 1986,
Prenatal diagnosis,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
September 1991,
Genomics,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
May 1991,
Genomics,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
January 1975,
Hereditas,
L R Carlock, and
D Skarecky, and
S L Dana, and
J J Wasmuth
October 1988,
Cancer research,
