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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. 2018
Dawn M Dudley, and
Koen K Van Rompay, and
Lark L Coffey, and
Amir Ardeshir, and
Rebekah I Keesler, and
Eliza Bliss-Moreau, and
Peta L Grigsby, and
Rosemary J Steinbach, and
Alec J Hirsch, and
Rhonda P MacAllister, and
Heidi L Pecoraro, and
Lois M Colgin, and
Travis Hodge, and
Daniel N Streblow, and
Suzette Tardif, and
Jean L Patterson, and
Manasi Tamhankar, and
Maxim Seferovic, and
Kjersti M Aagaard, and
Claudia Sánchez-San Martín, and
Charles Y Chiu, and
Antonito T Panganiban, and
Ronald S Veazey, and
Xiaolei Wang, and
Nicholas J Maness, and
Margaret H Gilbert, and
Rudolf P Bohm, and
Kristina M Adams Waldorf, and
Michael Gale, and
Lakshmi Rajagopal, and
Charlotte E Hotchkiss, and
Emma L Mohr, and
Saverio V Capuano, and
Heather A Simmons, and
Andres Mejia, and
Thomas C Friedrich, and
Thaddeus G Golos, and
David H O'Connor
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
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