Cervical myelography with metrizamide (Amipaque) was performed in 72 instances by lateral cervical puncture between C1 and C2, and in 21 instances by lumbar injection. A slight but significant difference in adverse reactions following the two methods was found. On comparing lumbar and cervical myelography using the lumbar approach a significantly higher incidence of nausea and vomiting following the cervical examination was demonstrated. No serious reactions occurred after either the lumbar or the cervical approach.