Down-regulation of testicular follicle-stimulating hormone receptors by human menopausal gonadotropin in infertile men. 1985

M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto

We measured testicular FSH receptors in 27 infertile men before, or 1, 3, 5, 7, or 14 days after a single administration of 150 IU of hMG. The administration of hMG reduced Bmax for FSH receptors to about 50% of that in the preadministration testes for 5 days. From the seventh day, Bmax of FSH receptors began to increase and returned to the preadministration level 14 days after the administration.

UI MeSH Term Description Entries
D007248 Infertility, Male The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility. Sterility, Male,Sub-Fertility, Male,Subfertility, Male,Male Infertility,Male Sterility,Male Sub-Fertility,Male Subfertility,Sub Fertility, Male
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008297 Male Males
D008596 Menotropins Extracts of urine from menopausal women that contain high concentrations of pituitary gonadotropins, FOLLICLE STIMULATING HORMONE and LUTEINIZING HORMONE. Menotropins are used to treat infertility. The FSH:LH ratio and degree of purity vary in different preparations. Gonadotropins, Human Menopausal,Human Menopausal Gonadotropin,CP-89044,CP-90033,HMG Ferring,HMG Lepori,HMG Massone,Humegon,Menogon,Menopur,Menotrophin,Normegon,ORG-31338,Pergonal,Pergonal-500,CP 89044,CP 90033,CP89044,CP90033,Gonadotropin, Human Menopausal,Human Menopausal Gonadotropins,Lepori, HMG,Menopausal Gonadotropin, Human,ORG 31338,ORG31338,Pergonal 500,Pergonal500
D011956 Receptors, Cell Surface Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D011962 Receptors, FSH Cell surface proteins that bind FOLLICLE STIMULATING HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. FSH Receptors,Follicle-Stimulating Hormone Receptors,Receptors, Follicle-Stimulating Hormone,FSH Receptor,Follicle-Stimulating Hormone Receptor,Follicle Stimulating Hormone Receptor,Follicle Stimulating Hormone Receptors,Hormone Receptor, Follicle-Stimulating,Hormone Receptors, Follicle-Stimulating,Receptor, FSH,Receptor, Follicle-Stimulating Hormone,Receptors, Follicle Stimulating Hormone
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining
D013737 Testis The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. Testicles,Testes,Testicle

Related Publications

M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
December 1971, The Journal of clinical endocrinology and metabolism,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
May 1995, The Journal of clinical endocrinology and metabolism,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
January 2013, Nature reviews. Urology,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
January 1990, Fertility and sterility,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
January 1986, Fertility and sterility,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
December 1982, The Journal of clinical endocrinology and metabolism,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
December 1994, Cell and tissue research,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
January 1987, International journal of fertility,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
January 1984, Obstetrics and gynecology,
M Namiki, and A Okuyama, and T Sonoda, and A Miyake, and T Aono, and K Matsumoto
March 2005, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
Copied contents to your clipboard!