-transparent.png){kind=logo}
A phase II study of vindesine (VDS) was carried out in 21 patients with non-small cell lung cancer (NSCLC). There were 13 and 8 patients with and without prior chemotherapy, respectively. VDS was administered at a weekly iv dose of 3 mg/m2. Partial response was observed in two of 15 adenocarcinomas and one of 2 adenosquamous cell carcinomas, and the overall response rate was 14.3% (3/21). Myelosuppression, especially leukopenia, was the most common dose-limiting side effect. Neurotoxicity was also a common side effect but the degree was mild. It was concluded that VDS at a dose of 3 mg/m2 every week seems to be active against NSCLC.
Related Publications
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
January 1992,
Anticancer research,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
August 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
February 1999,
British journal of cancer,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
January 1991,
European journal of cancer (Oxford, England : 1990),
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
January 1993,
Cancer chemotherapy and pharmacology,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
August 1979,
Cancer treatment reports,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
October 1991,
Acta medica Okayama,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
February 1992,
American journal of clinical oncology,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
January 1981,
Cancer treatment reports,
J Fujita, and
N Saijo, and
K Eguchi, and
T Shinkai, and
K Tominaga, and
Y Sasaki, and
H Futami, and
M Sakurai, and
J Ishihara, and
H Takahashi
May 1990,
Gan to kagaku ryoho. Cancer & chemotherapy,
