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The aim of this study was to investigate further the influence of dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on the functional activity of the pituitary-adrenocortical system in man. Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin. In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion. These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta-endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
March 1980,
The Journal of clinical endocrinology and metabolism,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
December 1978,
The Journal of clinical investigation,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
April 1985,
Endocrinology,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
July 1988,
Acta endocrinologica,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
January 1988,
Psychoneuroendocrinology,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
December 1989,
Endocrinology,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
October 1982,
Clinical science (London, England : 1979),
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
January 1990,
Acta cardiologica,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
April 1981,
Brain research,
E C Degli Uberti, and
F Petraglia, and
G Trasforini, and
S Salvadori, and
A Margutti, and
M Bianconi, and
V Teodori, and
F Facchinetti, and
R Tomatis, and
A R Genazzani
September 1985,
Endocrinology,
