-transparent.png){kind=logo}
Glycosylation of silylated 5-trimethylgermyluracil with 2-deoxy-3,5-di-O-p-toluyl-alpha-D-ribofuranosylchloride in dichloroethane in the presence of SnCl4 and subsequent deacylation led to anomeric 5-trimethylgermyl-2'-deoxyuridines. The alpha-nucleoside inhibits HSV-1 replication in vitro, blocks 2'-deoxyuridine incorporation into DNA of hepatoma 22A cells and incorporation of thymidine into DNA of cancer ovarian cells as well. Treatment with 125 mg/kg X 5 days of alpha-nucleoside fails to increase the life-span of mice with leukemia P388.
Related Publications
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
July 1964,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
May 1986,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
June 1991,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
August 1994,
Antiviral research,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
April 1986,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
February 1990,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
September 1988,
Journal of medicinal chemistry,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
January 1985,
Nucleic acids symposium series,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
April 1966,
Tetrahedron letters,
S Ia Mel'nik, and
A A Bakhmedova, and
T P Nedorezova, and
I V Iartseva, and
O S Zhukova
February 1992,
Drug design and discovery,
