-transparent.png){kind=logo}
Alpha-1 antitrypsin (AAT) phenotypes and serum levels were studied in two childhood perennial asthmatic populations. The first was an ambulatory, mostly mild nonsteroid-dependent group living in Rochester, N.Y. The second was a more severe mostly steroid-dependent group residing at an asthma residential treatment center in Denver, Colo. The prevalences of alpha-1 antitrypsin protease inhibitor (Pi) tyes were the same for bothe groups and similar to prevalences in a random population. Alpha-1 antitrypsin serum levels were significantly elevated for the mild nonsteroid-dependent group when compared to the more severe steroid-dependent group. The steroid-dependent group had serum levels similar to a group of nonasthmatic control children. These findings indicate that there is not a strong association of alpha-1 antitrypsin Pi variants such as Pi MZ or Pi MS with more severe asthma. Elevated serum levels in the milk perennial asthmatic group may be the result of chronic inflammatory processes. Normal levels in the sterioid-dependent group may be the result of corticosteroid control of inflammation associated with asthma.
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
December 1985,
Revue francaise de transfusion et immuno-hematologie,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
November 1980,
Current problems in pediatrics,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
January 1979,
Kinderarztliche Praxis,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
April 1974,
The American review of respiratory disease,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
July 1972,
The Proceedings of the Institute of Medicine of Chicago,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
April 1986,
Indian pediatrics,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
January 2011,
Fetal and pediatric pathology,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
July 1978,
Pediatrics,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
January 1973,
British journal of diseases of the chest,
R H Schwartz, and
J D Van Ess, and
D E Johnstone, and
E M Dreyfuss, and
M A Abrishami, and
H Chai
June 1994,
Chest,
