[Polish asbestos and its fibrogenic effect. II. Identification and fibrogenic effect of fibrous minerals occurring in road stone deposits]. 1985

H Woźniak, and E Wiecek

Fibrogenic properties of a fibrous mineral occurring in road stone deposits mined at Nasławice at the Lower Silesia have been tested. Diffractometric and infrared absorption spectra tests identified this mineral as antigorite. The content of free crystalline silica was 1.3%. The dust (50 mg) obtained from the test mineral when intratracheally administered to experimental animals as a suspension in physiological NaC1 solution yielded statistically significant increases of the lung weight and hydroxyproline content, as compared to controls. The mean weight of experimental animals' lungs after 3 months was 1898.4 mg, after 6 months--2116.8 mg, after 9 months--2878.4 mg. The control animals' lung weight was 1409.6 mg after 3 months, 1634.4 mg after 6 months and 1939.9 mg after 9 months. Hydroxyproline content in experimental animals' lungs was 5.1 after 3 months, 5.8 mg after 6 months and 8.6 mg after 9 months. In controls, hydroxyproline content in lungs was, respectively: 3.5; 3.9 and 4.0 mg after 3, 6, and 9 months of the experiment. However, the process of lung fibrosis when affected by antigorite from Nasławice was slower than under effects of antigorite from Szklary, which may result from almost 10 times fewer numbers of fibrous particles in the dust obtained from antigorite from Nasławice.

UI MeSH Term Description Entries
D008297 Male Males
D011044 Poland A country in central Europe, east of Germany. The capital is Warsaw. Polish People's Republic,Republic of Poland
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D004391 Dust Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed) House Dust,Housedust,Dust, House
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001194 Asbestos Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
D017632 Asbestos, Serpentine A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893) Chrysotile,Serpentine (Mineral),Serpentine Asbestos,Antigorite,Asbestos, Serpentine, Chrysotile (Mg3(OH)4(Si2O5))
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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