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We conducted a study to identify the viruses in tissue specimens of oral "hairy" leukoplakia, a lesion that is found in immunosuppressed male homosexuals and that is associated with the subsequent development of the acquired immunodeficiency syndrome. When stained for papillomavirus core antigen, 49 of 67 biopsy specimens (73 per cent) yielded positive results in epithelial-cell nuclei. Electron microscopy showed papillomavirus-like particles in all of 25 specimens, and the herpes-type virus described in a previous report was seen in 23 of the 25 specimens. Three specimens had both types of particle in the same individual epithelial cells. Immunofluorescence for herpes simplex virus, varicella-zoster virus, and cytomegalovirus gave negative results in all cases, but 19 of 20 specimens showed intense nuclear staining in epithelial cells for the viral capsid antigen of Epstein-Barr virus (EBV). DNA hybridization using EBV probes in Southern blots demonstrated EBV DNA in all of 13 specimens and found 200 or more viral DNA molecules per cellular genome in 11 of the 13. The whole EBV genome was also demonstrated in the specimens and found to be in linear virion form. We conclude that EBV replicates within the epithelial cells in hairy leukoplakia.
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
May 2004,
The Journal of infectious diseases,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
December 2000,
Research initiative, treatment action : RITA,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
January 1990,
Journal of virology,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
August 1993,
Virology,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
December 1994,
Journal of virology,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
April 1993,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
December 1991,
The American journal of pathology,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
March 1996,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
August 2002,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
J S Greenspan, and
D Greenspan, and
E T Lennette, and
D I Abrams, and
M A Conant, and
V Petersen, and
U K Freese
April 1989,
Oral surgery, oral medicine, and oral pathology,
