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Eight immunosuppressed homosexual men with cytomegalovirus viremia--seven with serious bilateral retinitis, one with colitis in addition to retinitis, and one with pneumonitis only--were treated with a new acyclovir derivative, 9-(1,3-dihydroxy-2-propoxymethyl) guanine, which has excellent in-vitro activity against cytomegalovirus. All patients had virologic and clinical improvement, but substantial leukopenia developed in three patients. Both clinical relapses and viral relapses occurred frequently, usually within 30 days after cessation of treatment. 9-(1,3-Dihydroxy-2-propoxymethyl) guanine represents the first clinically and virologically effective agent for the treatment of cytomegalovirus disease, but more effective and less toxic therapeutic regimens for both acute and chronic use must be developed.
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
August 1986,
Annals of internal medicine,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
February 1988,
Transplantation proceedings,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
October 1983,
Antimicrobial agents and chemotherapy,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
April 1986,
Annals of internal medicine,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
August 1989,
Ugeskrift for laeger,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
October 1985,
The Journal of infectious diseases,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
March 1986,
The New England journal of medicine,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
January 1987,
Antiviral research,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
June 1988,
Transplantation,
H Masur, and
H C Lane, and
A Palestine, and
P D Smith, and
J Manischewitz, and
G Stevens, and
L Fujikawa, and
A M Macher, and
R Nussenblatt, and
B Baird
February 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
