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The influence of diabetes on gingival inflammation was studied through its effect on prolyl and lysyl-hydroxylase activities and on tissue-collagen content. Inflammation induced for 7 days with either endotoxin or antigen-antibody complexes reduced the activity of both enzymes by about 45 per cent, and decreased the concentration of soluble and insoluble collagens. Diabetes alone decreased the enzyme activity by more than 50 per cent but prevented the loss of the soluble and insoluble collagens which occurs during inflammation. The complex interaction of diabetes and inflammation on collagen metabolism in gingival tissue may be explained in part by abnormalities of collagen synthesis; alterations in collagen maturation and degradation, and in leukocyte function, may also occur.
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
January 1983,
Archives of oral biology,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
September 1975,
Archives of biochemistry and biophysics,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
December 1985,
Life sciences,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
March 1981,
Biochemical and biophysical research communications,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
July 1979,
Biochemical and biophysical research communications,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
January 1977,
Research communications in chemical pathology and pharmacology,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
March 1975,
Biochimica et biophysica acta,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
August 1994,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
September 1985,
Archives of biochemistry and biophysics,
N S Ramamurthy, and
R A Greenwald, and
M Schneir, and
L M Golub
October 1974,
Gut,
