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An inquiry into the relation between exposure to silica dust, the presence of silicosis, and progressive systemic sclerosis was conducted in white South African gold miners by means of a case-control study. Seventy nine cases of progressive systemic sclerosis were matched by year of birth with an equal number of control miners selected randomly but bearing in mind the administrative channel through which the case had come to be identified. Analysis showed no association between silicosis and PSS but did show that the cumulative life time silica exposure was significantly higher in the cases compared with controls. This difference was due to a difference in the intensity of exposure to silica during mining service rather than a difference in duration of service. The results are discussed in the context of current thought on the aetiology of progressive systemic sclerosis, particularly in relation to autoimmune and genetic factors.
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
November 1965,
La Medicina del lavoro,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
January 1992,
Dermatology (Basel, Switzerland),
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
December 1995,
Journal de radiologie,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
May 1996,
American journal of industrial medicine,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
January 2013,
Revista brasileira de reumatologia,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
January 2017,
Indian journal of occupational and environmental medicine,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
October 1999,
The Journal of rheumatology,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
November 1963,
Journal of the Mississippi State Medical Association,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
January 1994,
Ryoikibetsu shokogun shirizu,
G K Sluis-Cremer, and
P A Hessel, and
E H Nizdo, and
A R Churchill, and
E A Zeiss
February 1968,
Journal de medecine de Lyon,
