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Autophagy is a key cellular mechanism involved in the degradation of long-lived proteins and organelles. We and others have previously shown that Schwann cells are able to degrade their own myelin by a form of selective autophagy, or myelinophagy. There is now increasing evidence that myelinophagy could also be aberrantly activated in other demyelinating diseases, including hereditary or inflammatory neuropathies, implicating this pathway in the pathogenesis of these disorders. In this chapter, we describe our protocol to monitor autophagy in peripheral nerves, using the autophagy flux assay. This assay can be useful to compare basal and demyelination-induced autophagy in genetic mice models, or after treatment with specific compounds.
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
November 2016,
International journal of radiation biology,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
January 2021,
Methods in cell biology,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
December 2010,
Proceedings of the National Academy of Sciences of the United States of America,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
January 2021,
Methods in cell biology,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
August 2003,
Science (New York, N.Y.),
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
February 2020,
Scientific reports,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
January 2014,
Methods in enzymology,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
April 2012,
Autophagy,
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
January 2018,
Methods in molecular biology (Clifton, N.J.),
Miguel Tamayo Caro, and
Marta Palomo Irigoyen, and
Encarnación Pérez Andrés, and
Adrián Barreira Manrique, and
Marta Varela Rey, and
Ashwin Woodhoo
September 2019,
Neural regeneration research,
